Neuroprotective Therapies after Perinatal Hypoxic-Ischemic Brain Injury
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Neuroprotective Therapies after Perinatal Hypoxic-Ischemic Brain Injury
Hypoxic-ischemic (HI) brain injury is one of the main causes of disabilities in term-born infants. It is the result of a deprivation of oxygen and glucose in the neural tissue. As one of the most important causes of brain damage in the newborn period, the neonatal HI event is a devastating condition that can lead to long-term neurological deficits or even death. The pattern of this injury occur...
متن کاملPharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury
Perinatal hypoxia-ischemia (HI) is an important cause of neonatal brain injury. Recent progress in the search for neuroprotective compounds has provided us with several promising drugs to reduce perinatal HI-induced brain injury. In the early stage (first 6 hours after birth) therapies are concentrated on prevention of the production of reactive oxygen species or free radicals (xanthine-oxidase...
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접수 : 2007년 12월 4일, 승인 : 2008년 1월 9일 이 연구는 2002년도 대구가톨릭대학교 의과학연구소 연구비의 지원으로 이루어졌음 책임저자 : 김우택, 대구가톨릭대학병원 소아과청소년과 Correspondence : Woo Taek Kim, M.D. Tel : 053)650-4250 Fax : 053)622-4240 E-mail : [email protected] xia at birth is estimates to be 0.2-0.4% in full-term newborn infants and approaches 60% in preterm infants. About 20-50% of infants suffering from H-I encephalopathy expire during the ...
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One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic-ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage and finally producing cell death. Effective therapeutic treatments against this...
متن کاملThe neuroprotective roles of BDNF in hypoxic ischemic brain injury.
Hypoxia-ischemia (H/I) brain injury results in various degrees of damage to the body, and the immature brain is particularly fragile to oxygen deprivation. Hypothermia and erythropoietin (EPO) have long been known to be neuroprotective in ischemic brain injury. Brain-derived neurotrophic factor (BDNF) has recently been recognized as a potent modulator capable of regulating a wide repertoire of ...
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ژورنال
عنوان ژورنال: Brain Sciences
سال: 2013
ISSN: 2076-3425
DOI: 10.3390/brainsci3010191